★【medlife】3-Hydroxy-4-methoxycinnamic acid

Medlife小分子 2024-03-20

3-Hydroxy-4-methoxycinnamicacid(Isoferulicacid)是具有抗糖尿病活性的肉桂酸衍生物。3-Hydroxy-4-meth

3-Hydroxy-4-methoxycinnamic acid (Isoferulic acid) 是具有抗糖尿病活性的肉桂酸衍生物。3-Hydroxy-4-methoxycinnamic acid 结合并激活 α1-肾上腺素能受体 (IC50=1.4 μM)，增强 β-内啡肽的分泌 (EC50=52.2 nM) 并增加体外葡萄糖的使用。

中文名称

[优选]3-Hydroxy-4-methoxycinnamic acid

中文别名

3-羟基-4-甲氧基肉桂酸;3-羟基-4-甲氧基苯乙烯酸;异阿魏酸;3-羟基-4-甲氧基桂皮酸;异阿魏酸标准品;异阿魏酸(P);异阿魏酸植物提取物,标准品,对照品;3-(3-羟基-4-甲氧基苯基)-2-(E)-丙烯酸;3-羟-4-甲氧桂皮酸;分析对照品;橘皮酸;异阿魏酸对照品;异阿魏酸对照品,标准品,中草药;異阿魏酸

英文名称

3-Hydroxy-4-methoxycinnamic acid

英文别名

3-(3-Hydroxy-4-methoxyphenyl)acrylic acid;(2E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoic acid;Isoferulic acid;3-Hydroxy-4-methoxycinnamic acid;3-Hydroxy-4-methoxycinnamic Acid (Isoferulic Acid);ISOFERULIC ACID(P) PrintBack;ISOFERULIC ACID(RG);3'-hydroxy-4'-methoxy cinnamic acid;3-Hydroxy-4-methoxycinnamic;Caffeic acid 4-methyl ether;Hesperetic Acid;HESPERETINIC ACID;Hesperitinic acid;Isoferulic;RARECHEM BK HW 0093;trans-3-hydroxy-4-methoxycinnamic acid;trans-isoferulic acid;WAKO085-08691;Cinnamicacid, 3-hydroxy-4-methoxy- (7CI,8CI);4-Methoxycaffeic acid;4-O-Methylcaffeic acid;NSC 51987;Isoferulicacid;Isoferulate;Hesperetate;(E)-3-(3-hydroxy-4-methoxyphenyl)acrylic acid;2-Propenoic acid, 3-(3-hydroxy-4-methoxyphenyl)-;3-(3-hydroxy-4-methoxyphenyl)prop-2-enoic acid;3-hydroxy-4-methoxy-cinnamic acid;QURCVMIEKCOAJU-HWKANZROSA-N;Cinnamic acid, 3-

Cas No.

537-73-5

分子式

C10H10O4

分子量

194.18

包装储存

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

Isoferulic acid (3-Hydroxy-4-methoxycinnamic acid) is a cinnamic acid derivative that has antidiabetic activity. Isoferulic acid binds to and activates α1-adrenergic receptors (IC50=1.4 μM) to enhance secretion of β-endorphin (EC50=52.2 nM) and increase glucose use. Isoferulic acid also has anti-influenza virus activities.

性状

Solid

IC50 & Target[1][2]

α adrenergic receptor

运输条件

Room temperature or refrigerated transportation.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

结构分类

来源

参考文献

[1]. Liu IM, et al. Mediation of beta-endorphin by isoferulic acid to lower plasma glucose in streptozotocin-induced diabetic rats. J Pharmacol Exp Ther. 2003 Dec;307(3):1196-204. [Information]
[2]. Sakai S, et al. Administration of isoferulic acid improved the survival rate of lethal influenza virus pneumonia in mice. Mediators Inflamm. 2001 Apr;10(2):93-6. [Information]

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★【medlife】3-Hydroxy-4-methoxycinnamic acid

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