[Medlife]SAR191801|1234708-04-3
简介:hPGDS-IN-1是一种hPGDS抑制剂, 荧光偏振检测或EIA法测得IC50值为12 nM。
HPGDS-IN-1物理化学性质:
分子式 | C22H20N6O3 |
---|---|
分子量 | 416.43300 |
精确质量 | 416.16000 |
PSA | 126.92000 |
LogP | 3.13690 |
HPGDS-IN-1详细介绍:
中文名称: | SAR191801 抑制剂 |
中文别名: | N-[[3-[5-(1-羟基-1-甲基乙基)-1,2,4-恶二唑-3-基]苯基]甲基]-2-(2-吡啶基)-5-嘧啶甲酰胺 |
英文名称: | SAR191801 |
英文别名: | SAR191801;hPGDS-IN-1 |
CAS号: | 1234708-04-3 |
分子式: | C22H20N6O3 |
分子量: | 416.43 |
详细描述 | Medlife,致力于提供高品质、高性价比小分子化合物的产品。Medlife小分子化合物大量库存,提供超过2万种的抑制剂、激动剂、拮抗剂等产品,是药物及疾病研究的重要原料供应商。hPGDS抑制剂。hPGDS-IN-1是一种hPGDS抑制剂, 荧光偏振检测或EIA法测得IC50值为12 nM。 |
HPGDS-IN-1参考文献:
[1]. Vandeusen, Christopher L, et al. Phenyloxadiazole derivatives as PGD inhibitors and their preparation, pharmaceutical compositions and use in the treatment of allergic and inflammatory disorders. From PCT Int. Appl. (2011), WO 2011044307 A1 20110414.
[2]. Hahn Chang S. Method for treating macular degeneration using syk multikinase inhibitor, an hPGDS inhibitor and a DP antagonist. From PCT Int. Appl. (2010), WO 2010080563 A2 20100715.
[3]. Weiberth Franz J, et al. Demonstration on Pilot-Plant Scale of the Utility of 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD) as a Catalyst in the Efficient Amidation of an Unactivated Methyl Ester. From Organic Process Research & Development (2012), 16(12), 19
Medlife品牌是国内知名的小分子化合物品牌,致力于信号通路、抑制剂、激动剂等产品的研发及产品供应服务,同时还可提供重组蛋白、植提、寡核苷酸等系列的产品。
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